Effects of Melatonin Administration on Chemical Pregnancy Rates of Polycystic Ovary Syndrome Patients Undergoing Intrauterine Insemination: A Randomized Clinical Trial

نویسندگان

  • Amir Almasi-Hashiani Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  • Fataneh Mokhtari Department of Obstetrics and Gynecology, IVF Unit, Yas Hospital, Tehran University of Medical Sciences, Tehran, Iran
  • Firoozeh Akbari asbagh Department of Obstetrics and Gynecology, IVF Unit, Yas Hospital, Tehran University of Medical Sciences, Tehran, Iran
  • Mahmood Bakhtiyari Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
چکیده مقاله:

Objective Background: Oxidative stress as a potential cause of poor oocyte quality can influence female reproduction. This study aimed to investigate the effects of melatonin on chemical pregnancy rates of a significant number of polycystic ovary syndrome (PCOS) patients undergoing intrauterine insemination (IUI). MaterialsAndMethods Materials and Methods: In this randomized double-blinded clinical trial, the study samples included 198 PCOS patients fulfilling the inclusion criteria and undergoing the IUI treatment. On the third day of menstruation, a 3-mg melatonin tablet or its placebo was given to the patients according to the randomized study protocol; this prescription was continued until the day of HCG administration. The current study attempted to primarily scrutinize the effect of melatonin administration on the rate of chemical pregnancy and mature follicles during the IUI treatment cycle and secondary determine the endometrial thickness on the day of IUI. Results Results: The mean age of the participants in the study was 28.9 ± 5.5 years. The chemical pregnancy rate in the group receiving melatonin was about 32%, and this value was 18% in the control group (P = 0.012). Furthermore, it was concluded that the addition of melatonin to the treatment cycle of PCOS individuals could significantly improve the endometrial thickness after the treatment (P

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

P-189: Effect of Piroxicam Administration on Pregnancy Rate in Intrauterine Insemination (IUI) Cycles: A Randomized Clinical Trial

Background: To investigate the effect of administering piroxicam on improving the success rate of IUI cycles in those suffering from unexplained infertility. Materials and Methods: This was a randomized clinical trial being performed at Ghadir Mother and Child Hospital and Motahari clinics of Shiraz University of Medical Sciences. We included 260 women with unexplained infertility selected for ...

متن کامل

Comparison of the Effects of Desoceptive and Etisterone Pills on the Clinical, Hormonal, and Metabolic Findings of Patients with Polycystic Ovary Syndrome: A Randomized Clinical Trial

Introduction: Oral contraceptives (OCs) have been recommended as the first-line drug therapy for polycystic ovary syndrome (PCOS). This study aimed to compare the effectiveness of Desoceptive and Etisterone OCs on the clinical, hormonal, and metabolic parameters of patients with PCOS over six months. Materials and Methods: In this randomized clinical trial, 200 patients with PCOS were randomly ...

متن کامل

Evaluation of the Efficacy and Side Effects of Catheter-Specific Intrauterine Insemination in Infertile Couples, a Randomized Clinical Trial

Introduction: Intrauterine insemination (IUI) is one of the assisted reproductive techniques, which increases the likelihood of egg being exposed to sperm in the uterus and thus the chances of pregnancy. The purpose of the present study was to compare the efficiency of the Masstec catheter (the internal product) with imported catheter (PMIU) so that, if similar, use domestic production as an al...

متن کامل

the effects of endometrial injury on intrauterine insemination outcome: a randomized clinical trial

background: implantation is considered as the rate-limiting step in success of assisted reproduction techniques, and intrauterine insemination cycles. it might be affected by ovarian superovulation and endometrial local scratching. objective: this study aims to investigate the effect of local endometrial injury on the outcome of iui cycles. materials and methods: in this randomized clinical tri...

متن کامل

Effect of Early Mobilization on Hemodynamic Parameters of Patients Undergoing Sleeve Gastrectomy; A Randomized Clinical Trial

Aims: Today, due to the failure of non-surgical methods in the treatment of obesity, surgical procedures such as sleeve gastrocetomy are used. Similar to other invasive interventions, sleeve gastrectomy causes an imbalance in hemodynamic parameters. The aim of this study was to determine the effect of early mobilization on hemodynamic parameters in patients undergoing sleeve gastrectomy. Mater...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ذخیره در منابع من قبلا به منابع من ذحیره شده

{@ msg_add @}


عنوان ژورنال

دوره 13  شماره 3

صفحات  225- 229

تاریخ انتشار 2019-07-01

با دنبال کردن یک ژورنال هنگامی که شماره جدید این ژورنال منتشر می شود به شما از طریق ایمیل اطلاع داده می شود.

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023